Cognitive Flexibility and Mindfulness. // Melanie Boling, Graduate Student of Neuropsychology, Harvard University

“Mindfulness is the basic human ability to be fully present, aware of where we are and what we’re doing, and not overly reactive or overwhelmed by what’s going on around us” (Mindful.org, 2021).

Cognitive flexibility, the ability to flexibly switch between tasks, is a core dimension of executive functions (EFs) allowing to control actions and to adapt flexibly to changing environments (Buttleman, 2017).

Mindfulness increases the connectivity between the Anterior Cingulate Cortex (ACC), responsible for the emotional and cognitive center of the brain; and the Posterior Circulate Cortex (PSC), the hub of the Default Mode Network which provides a sense of self and your own perception on reality (Murphy-Beiner & Soar, 2020).

Strengthening those connections through mindfulness and cognitive flexibility will help self-regulate and achieve homeostasis when the allostatic load becomes unstable, which contributes to HPA-axis and dopamine dysfunction (Murphy-Beiner & Soar, 2020).

“Ayahuasca’s afterglow: Improved mindfulness & cognitive flexibility.” Ashleigh Murphy-Beiner


(Six Tips to Build Self-Efficacy for Success, 2018.)


Mastering the Art of Self-Efficacy.

“Self-Efficacy describes belief in your own abilities...belief you can  achieve your goals, belief you can resolve challenges, belief you can overcome obstacles, belief you can stay committed, belief you can be  resilient, and importantly belief you can realise your vision. A robust belief in you...underpinned by your own evidence” (Six Tips to Build Self-Efficacy for Success, 2018.)


(Razzaq et al., 2018)

“Self-efficacy reflects confidence in the ability to exert control over one's own motivation, behavior, and social environment.

These cognitive self-evaluations influence all manner of human experience, including the goals for which people strive, the amount of energy expended toward goal achievement, and likelihood of attaining particular levels of behavioral performance.

Unlike traditional psychological constructs, self-efficacy beliefs are hypothesized to vary depending on the domain of functioning and circumstances surrounding the occurrence of behavior” (Self-Efficacy Teaching Tip Sheet).

Self-Efficacy Theory (Lippke, 2020) has had considerable influence on research, education, and clinical practice. In the field of behavioral psychology, for example, the construct of self-efficacy has been applied to behaviors as diverse as:

  • Self-management of chronic disease

  • Smoking cessation

  • Alcohol use

  • Eating

  • Pain control

  • Exercise

  • Dopamine Control

  • Emotional Regulation

  • Educating others to understand the differences among constructs from related social-cognitive theories (e.g., self-efficacy, behavioral difficulty, self-esteem, optimism, etc.).

  • Empowering others to develop a personalized measure of self-efficacy for any health-related behavior that avoids the confounding of self-efficacy with these other constructs.

  • “If behaviors are socially stigmatized, or if social norms suggest that one should engage frequently in a specific behavior or set of behaviors, discuss how social desirability response biases might inflate self-efficacy scores” (Self-Efficacy Teaching Tip Sheet, n.d.).

  • Discuss self-efficacy measurements and statistical (e.g., transformation of data) solutions to such problems.

  • Encourage practitioners to develop methods to assemble evidence for the validity of their self-efficacy measure.

  • Help practitioners to design personal goals that will enhance self-efficacy, and a research design to measure changes in self-efficacy and whether these changes alter risky behaviors in a positive or negative way.


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About the author:

Melanie began attending Harvard in 2020 to complete a Graduate Certificate in Human Behavior with a specialization in Neuropsychology. Boling’s research has examined extreme environments and how they can have a potential negative impact on humans operating in the extreme environment. During her time at Harvard, she has built a mental wellness tool called a psychological field kit. Implementing these tools will allow an individual to thrive in an extreme environment while mitigating negative variables such as abnormal human behavior which can play a role in team degradation.

Melanie Boling, Extreme (ICE) Environments Neuroscientist, Boling Expeditionary Research Group; and Neuropsychology Graduate Student, Harvard University.

Psychedelic-Assisted Therapy: Ketamine Edition // Melanie Boling, Harvard University; Boling Expeditionary Research

Psychedelic-Assisted Therapy: Ketamine Edition with Field Trip Health // Melanie Boling, Harvard University, Boling Expeditionary Research.


Ketamine is considered a disassociative anesthetic with psychedelic properties that has unique effects on the body and mind. Ketamine acts on receptors in the brain that can lead to the reduction of depressive symptoms. Currently, Ketamine is the only legal psychedelic medicine available to mental health providers in the United States for the treatment of emotional suffering.

“Psychedelic experiences to promote mental wellness and healing are the result of their ability to temporarily suspend the Default Mode Network (DMN) of the brain.

The DMN is a section of correlated parts of the brain consisting primarily of the prefrontal cortex (PFC), posterior cingulate cortex (PCC), and inferior parietal lobe (IPL). As the brain matures, the DMN starts to rely more consistently on certain pathways and algorithms that become habitual. This is our brain's way of optimizing energy consumption, by helping us to think more efficiently. This certainly has its benefits, but it also makes learning new behaviors or changing habits more challenging.

The DMN is thought to be responsible for our ego. The personality is comprised of three elements: the id, the ego, and the superego. The id consists of our primal desires and urges, while the superego is the moral compass that operates from internalized rules we acquire from our caregivers and society. The ego is the mediator between the urges of the id, the idealistic standards of the superego, and the demands of reality. The ego then forms the identity that helps us fit in the works, it defines who we are ourselves and how we project ourselves to the world.

During a psychedelic experience, where “ego dissolution” occurs, the DMN shuts down temporarily. This suspension of the DMN allows access to parts of the brain and functions that are not typically used and as a result, helps our consciousness access to new perspectives.

Through the lens of psychology, psychedelics suspend the ego’s grip, enabling you to get an objective view of your current definition of self, thus creating opportunities for change. In other words, it helps you get out of your own way.” - The Trip Journal


About the author:

Melanie began attending Harvard in 2020 to complete a Graduate Certificate in Human Behavior with a specialization in Neuropsychology. Boling’s research has examined extreme environments and how they can have a potential negative impact on humans operating in the extreme environment. During her time at Harvard, she has built a mental wellness tool called the psychological field kit. Implementing these tools will allow an individual to thrive in an extreme environment while mitigating negative variables such as abnormal human behavior which can play a role in team degradation. In 2023, she will also complete Harvard’s Graduate Certificate in Biology with a focus on Neurobiology and Neurophysiology. Melanie currently serves as Deputy Director of Communications for Harvard Veterans Alumni Organization, and in November 2022 she was elected as the Outreach and Communications Officer for the Pacific Northwest Chapter of The Explorers Club.

Melanie recently opened her Behavioral Neuroscience Field Research and Holistic Health Consulting Business, Boling Expeditionary Research. Melanie plans to return to the field to test her research before applying to a Ph.D. program in Behavioral Neuroscience.

Melanie Boling, Founder of Boling Expeditionary Research climbing the Enchantments of Leavenworth, Washington.

Music Therapy in the Andes Mountains. // Melanie Boling, Extreme Environments Behavioural Ecologist, Peer Wild.

“Let the music set you free”.


About the author:

“Boling's research is part of her Graduate Studies at Harvard University where she examines "extreme environments" and how they can have potential negative impacts on humans operating in the extreme environment. Implementing "psychological field kits" are a way of mitigating negative variables such as abnormal human behavior and abnormal human psychology that can play a role in team degradation.”

Melanie Noelani Boling, Extreme (ICE) Environments Behavioural Ecologist, Peer Wild; and Graduate Student of Neuropsychology, Harvard University.

Melanie Noelani Boling, Extreme (ICE) Environments Behavioural Ecologist, Peer Wild; and Graduate Student of Neuropsychology, Harvard University.

contact: melanie.noelani@gopeerwild.org

contact: melanie.noelani@gopeerwild.org

Critical Analysis of "All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors." // Melanie Boling, Harvard University.

A Critical Analysis of “All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493870/

Adobe Stock.

Hypothesis

D2 is a central target for antipsychotic action and anti-Parkinson action, whether any particular property of D2 may be related to dopamine supersensitivity and schizophrenia.

Risk factors or altered genes that lead to dopamine supersensitivity can also increase the risk for psychosis or schizophrenia. Antipsychotics and agonists target the dopamine D2 receptor.

Antipsychotic clinical doses correlate with their affinities for the dopamine receptor in a state of high affinity (D2High) or low affinity (D2Low).

D2High receptors are consistently elevated in the animal models of the various human psychoses.

Thus, it is reasonable to consider and test whether D2High is a common target for the convergence of the various psychosis pathways (Seeman, 2011).

Dr. Greg Dunn.

Critical Methods

  • Review why schizophrenics are super sensitive to dopamine-like drugs.

  • Review if D2High state is a basis for dopamine hypersensitivity in animal models of schizophrenia.

  • Review Common Biomarkers:

    • Dopamine Supersensitivity.

    • Common Target for antipsychotics.

    • Supersensitivity is related to D2 density and D2High receptors.

    • Deletion of genes.

    • Environmental factors.

    • Birth Injury by cesarean section.


Critical Results

The results conclude that all animal models of schizophrenia exhibit:

  • Elevations in D2High receptors.

  • Brain lesions.

  • Drug-induced hypersensitivity.

  • Birth injury.

  • Social isolation.

  • Gene deletions in neural pathways for:

    • NMDA.

    • Dopamine.

    • GABA.

    • Acetylcholine.

    • Norepinephrine.


Conclusion

  • Multiple abnormal pathways align through a common pathway of dopamine hypersensitivity and elevated D2High receptors, triggering psychosis.

  • Antipsychotics alleviate psychosis and reverse the elevation of D2High. They remain attached for days, preventing relapse; accumulation induces tardive dyskinesia.

  • Clozapine and quetiapine are released from D2 within 12 to 24 hours and do not elicit parkinsonism or tardive dyskinesia.

  • Long-term use of antipsychotics drives ongoing dopamine hypersensitivity.
    Switching from a traditional antipsychotic to an agonist (aripiprazole) can result in psychosis.

“Many risk factors lead to elevated D2High receptors and dopamine supersensitivity that underlie signs and symptoms of schizophrenia” (Seeman, 2011).

  • Future goals include imaging D2High receptors and desensitizing them in early-stage psychosis.

My Conclusion

  • The dissociation constant of a particular antipsychotic often differs among laboratories; while the results may have a somewhat similar outcome, the variables at play will alter the results from lab to lab.

  • Dopamine supersensitivity may be a basis for the positive signs and symptoms of psychosis, the underlying biology and hit’s relation to negative aspects of psychosis, such as cognition, is still unknown.

  • D2 receptor remains the central location and target for antipsychotics and antiparkinson drugs. It is best to avoid all psychostimulants in conjunction with antipsychotics due to the uptick in psychosis and drives supersensitivity within the individual.

  • The development of additional symptoms such as tardive dyskinesia depends on the long-term accumulation of antipsychotics on D2 receptors.


“Many risk factors lead to elevated D2High receptors and dopamine supersensitivity that underlie signs and symptoms of schizophrenia” (Seeman, 2011).

  • The hypothesis has been proven that multiple abnormal pathways align through a common pathway of dopamine hypersensitivity and elevated D2High receptors, triggering psychosis.

adobe stock.

References

Seeman, P. (2011). All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors. CNS Neuroscience & Therapeutics, 17(2), 118–132. https://doi.org/10.1111/j.1755-5949.2010.00162.x

 

 

About the author:

Melanie began attending Harvard in 2020 to complete a Graduate Certificate in Human Behavior with a specialization in Neuropsychology. Boling’s research has examined extreme environments and how they can have a potential negative impact on humans operating in the extreme environment. During her time at Harvard, she has built a mental wellness tool called a psychological field kit. Implementing these tools will allow an individual to thrive in an extreme environment while mitigating negative variables such as abnormal human behavior which can play a role in team degradation.

 

Melanie Boling, Extreme Environments Neuroscientist, Founder of Boling Expeditionary Research Group; and Neuropsychology Graduate Student, Harvard University.