Drawing from neuroscience, psychology, and psychopathology, we explore how the dysregulated brain circuits of Cluster B individuals (including hyperactivation of the amygdala, hypoactivity in the prefrontal cortex, and disruptions in the mirror neuron system) interact with the psychological vulnerabilities of enablers. Neurobiological stress responses in victims, including chronic dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and maladaptive fear conditioning, are analyzed as mechanisms by which enablers inadvertently reinforce maladaptive behaviors.

We also consider the dynamics of institutional betrayal, particularly in law enforcement and organizational settings, where women in enabling roles may normalize, minimize, or dismiss abuse. This interdisciplinary synthesis emphasizes the need for a paradigm shift in both clinical and societal responses to Cluster B-related abuse, recognizing enablers as critical actors in maintaining cycles of harm.